Endocrine Abstracts

Introduction: The aim of our experimental study was to investigate the effect of both T2DM and metformin treatment on myocardial tolerance to ischemia-reperfusion injury and cardiac AMP-activated protein kinase (AMPK) activity.Methods: The protocol included four groups: i) controls (n=13) – non-diabetic rats treated with i.p. vehicle injections for 3 days prior to the heart perfusion, ii) controls+metformin (CM; n=12) – non-diabet...

Context: Decreased levels of both vitamin D and insulin-like growth factor 1 (IGF1) may be associated with obesity, however this had not been well established. We have examined the relationship of vitamin D status and circulating IGF1 with metabolic parameters in abdominal obesity women.Methods: Serum 25(OH)D and IGF1 levels were measured by means of ELISA in 90 women (mean age 45.6±4.3) with abdominal obesity (according to IDF criteria, 2005). Anth...

It is well known that subclinical hypothyroidism (SH) more often can be revealed in patients with heart ischemic disease (HID). Mild thyroid failure can cause decrease of catabolism at atherogenic lipoproteins, decrease of cardiac output and diastolic disfunction of left ventricle. Results of coronarography (CG) can reliable reflect the severity of coronary atherosclerosis. It seems to us very important to compare the results of CG with TSH level and lipoproteins in heart isch...

Introduction: Weight loss is a key initial treatment strategy in obese women with polycistic ovary syndrome (PCOS) and improves insulin sensitivity and metabolic risk factors. In some women with PCOS it may reduce hyperandrogenism and restore menstrual function, ovulation and fertility. The aim of this study was to reveal clinical predictors of menstrual response to weight loss in overweight women with PCOS.Design: overweight unovulatory women with PCOS ...

Introduction: Gestational diabetes mellitus (GDM) is a common complication of pregnancy. Identification of early determinants of GDM is necesary to designate possible preventive strategies. The aim of this study was to reveal the most significant risk factors for GDM.Design: A total of 209 women with singleton pregnancies were included in the study. Maternal fasting glucose, anthropometric parameters and blood pressure were measured in the first trimeste...

Introduction: Metformin is now one of the most common treatments for PCOS. However controversy exists about the usefulness of metformin in PCOS women with normal insulin sensitivity and normal weight. The aim of this study was to compare efficacy of metformin treatment for the purpose of restoration of ovulation in lean and obese women with polycystic ovary syndrome.Design: Thirty-six unovulatory women with PCOS (21 lean with mean body mass index (BMI) 2...

Introduction: Anti-Müllerian hormone (AMH) has an inhibitory role during folliculogenesis, which may contribute to anovulation in polycistic ovary syndrome (PCOS). AMH level has been shown to be a predictor of reproductive response to weight loss and clomiphene citrate in women with PCOS. The aim of this study was to evaluate the role of AMH as a predictor of improvements in menstrual cyclicity and ovulation induction by metformin in lean women with PCOS.<p class="abs...